Does HRT make you gain weight?

Weight gain is a major concern facing many women during their menopause journey. And one question I hear a lot is “Will HRT make me gain weight?”

But before I address that specific question, it’s important to look at the background issues. According to the World Health Organisation statistics, there are 1.9 billion adults worldwide who are overweight and 23% of women in the UK are obese.

We know that obesity is a major risk factor for heart disease, high blood pressure, stroke, diabetes and osteoarthritis. It is also an independent risk factor for cancer including breast, uterus, ovarian and bowel. It increases women’s likelihood of having hot flushes and sweats and that these symptoms will last longer. It also often brings with it an increase in anxiety and depressive symptoms, which in themselves can create a vicious cycle that prevents weight loss.

During the menopause transition, weight increases roughly 0.5kg each year. This weight gain is influenced by a complex combination of factors – some of which will depend on socioeconomic status, education, family tendency, depression, medication, level of physical activity, and some on menopausal hormonal changes.

During the perimenopause and menopause, the egg follicles reserves contained within the ovaries are depleted. They produce the majority of our oestrogen that circulates around the bloodstream and perform essential functions in various tissues in the body. This drop in oestrogen levels results in a change of the fat distribution in the body resulting in “central abdominal obesity” – what we often think of as middle-age spread.

There is usually an increase in the waist circumference and in body fat, resulting in an increase in BMI (body mass index). This weight change can also bring with it unfavourable changes to blood pressure and cholesterol levels, and a higher risk of developing diabetes.

Back to HRT – will it make you gain weight?

As with many things menopause related, there is no definite answer –  it depends on the type of HRT and to each woman’s personal response to hormones.

HRT is either given as oestrogen alone if a woman has had a hysterectomy or has a Mirena coil inserted, or in combination with a progestogen if a woman still has a uterus.

In theory, the oestrogen component should not cause weight gain, and in some women it can reduce the central abdominal obesity and reduce their risk of developing diabetes. It can be the type of progestogen used in the HRT that can affect weight gain and it is worthwhile reviewing your previous response to hormones and the range of options available with your GP. The choice of HRT will depend on each woman’s personal circumstances and there is no one size fits all.

I approach each woman as an individual and assess their past experience with hormones – either contraceptives or HRT –  and try and tailor their treatment regime accordingly. The majority of women I have treated have not had to stop HRT because of weight gain, but roughly 5% of women will be sensitive to all hormones and may experience side effects that are not commonplace.

Remember also, during the perimenopause your own natural hormones are fluctuating so weight gain may not be due to HRT.

HRT is only one factor and looking at lifestyle around the menopause is essential for long-term health. Exercise reduces body fat and increases muscle, helps reduces stress levels, depressive symptoms and improves sleep. Diet is also very important alongside keeping a moderate alcohol intake.

Does gaining weight on the pill make it more likely you’ll gain weight with HRT?

The combined hormonal contraceptive pill and the progesterone only pill contain a variety of combinations of different oestrogens and progestogens and some of those are similar to certain HRT products but they are often delivered either in a different method or in a different dose combination. So gaining weight with the contraceptive pill does not necessarily mean that will happen with HRT and there are many products to choose from.

What to do if you think your HRT is making you gain weight

 It is important after starting any new HRT regime to have a three-monthly review with your doctor to assess response to treatment and discuss any side effects. There are a range of HRT preparations and it may take time to find the method that best suits you.

Most HRT that is commonly prescribed contains the same oestrogen component, 17B Oestradiol, which is identical in chemical structure to the oestrogen that the ovaries produce and so is referred to by some clinicians as ‘body identical’. This can be prescribed in the form of a tablet, patch or gel (pump dispenser or sachets).

The progestin component differs according to each product and this is what is sometimes responsible for changes in weight. There is currently only one licensed progesterone which is ‘body identical’ which can be taken as a capsule either orally or inserted in the vagina as a pessary. If a woman is experiencing weight gain it maybe that a body identical hormone would be more suitable but again this depends on personal background medical history, bleeding pattern and individual circumstances.

The aim with all forms of HRT is to control symptoms at the lowest effective dose, so if you are particularly sensitive to hormones you can start at a low dose and review your response at three months.

Gaining weight is therefore not a foregone conclusion with HRT, and it’s important to get to know your body’s responses and keep on monitoring your symptoms and progress.

Suzanne Saideman

About Suzanne Saideman

I am a GP and Menopause Specialist (certified by the British Menopause Society) and have an Advanced Certificate in Menopause Care. I am a Member of the Royal College of General Practitioners, have a Diploma in Sexual and Reproductive Health and a Letter of Competence in IUD and IUS fitting. I currently work part time in a busy NHS GP Practice in Edgware. I am passionate about empowering women to understand the menopause better and the range of symptoms that can affect quality of life and work together to make informed choices to suit their individual needs. I run a weekly menopause clinic on Thursdays in Elstree - find out more at my website